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KMID : 1234420100380030289
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Korean Journal of Microbiololgy and Biotechnology
2010 Volume.38 No. 3 p.289 ~ p.294
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Yam (Dioscorea spp.) has been used as important edible and medicinal natural Antibiotics against Dental Caries Pathogens
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Jang Kyeung-Ae
Kim Hye-Young
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Abstract
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Salvia miltiorrhiza Bunge (S. miltiorrhiza) is a traditional Korean medicine that is commonly used for the treatment of inflammatory diseases such as edema, arthritis, and hepatitis. The present study investigated the antimicrobial activity of methanol (MeOH) extract of S. miltiorrhiza roots against oral bacteria using broth the microdilution method and the checkerboard and time-kill methods evaluated the synergistic effects of treatment with antibiotics. The MeOH extract was demonstrated as a higher antibacterial activity (MICs, 8 to 64 μg/mL; MBCs, 16 to 64 μg/mL) against all tested oral bacteria. Additionally, the extract was observed to have a synergistic effect with ampicillin or gentamicin. A time-kill study evaluating the effects of the extract indicated that the extract treatment in combination with ampicillin or gentamicin showed rapid bactericidal activity. The results suggest that MeOH extract of S. miltiorrhiza could be employed as a natural antibacterial agent against dental caries.
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KEYWORD
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Salvia miltiorrhiza, Antibacterial activity, Dental caries, Oral bacteria, Minimum inhibitory concentrations/minimum bactericidal concentrations, Time-kill curves, Fractional inhibitory concentrations
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